Indapamide is rapidly and almost completely absorbed in the gastrointestinal tract. Ingestion absorption slows, but does not significantly affect the amount of adsorbed formulation. Maximum plasma concentration achieved after 12 hours after a single dose. Repeated receptions fluctuations in drug concentration in the blood plasma into the gap between the two doses are smoothed.
However, there are individual differences in individual patients.
Indapamide binds to plasma proteins is 79%, half-life is from 14 to 24 hours (mean 18 hours). Repeated primobolan steroid intake does not lead to drug accumulation in the body.
It is metabolized in the liver. 70% of indapamide mainly excreted by the kidneys as metabolites (fraction of unchanged drug is about 5%). About 20% is excreted in the feces as inactive metabolites.
Patients with inadequate renal function, the pharmacokinetic parameters of the drug did not significantly change.
- arterial hypertension
- hypersensitivity to any component of the drug and other sulfonamide derivatives;
- severe renal insufficiency (anuria stage)
- hepatic encephalopathy or severe hepatic insufficiency,
- concomitant use of drugs prolonging the interval QT (see. section Interaction with other medicinal products)
- age of 18 years primobolan steroid (effectiveness and safety have been established)
Diabetes mellitus, renal dysfunction and / or liver disease, disorders of water and electrolyte balance, hyperparathyroidism, patients with an increased QT interval on an electrocardiogram or receiving combination therapy, hyperuricemia (especially accompanied by gout or urate nephrolithiasis).
Pregnancy and lactation
reception indapamide during pregnancy is not recommended. Use of the drug can cause placental ischemia with the risk of fetal growth retardation. Do not use the drug during lactation (indapamide passes into breast milk).
Dosage and administration
: Inside, 1 tablet once a day, preferably in the morning, drinking plenty of fluids.
Side effect On the part of the cardiovascular system: orthostatic hypotension, ECG changes (hypokalemia), arrhythmia, palpitations. On the part of the central nervous system: headache, dizziness, nervousness, fatigue. From primobolan steroid the digestive system: constipation or diarrhea, dyspepsia, nausea, , abdominal pain, may develop hepatic encephalopathy, rarely pancreatitis. From the urogenital system:frequent infections, nocturia, polyuria. Allergic reactions: itching, maculopapular rash, urticaria, a hemorrhagic vasculitis. respiratory system: cough, pharyngitis, sinusitis. Laboratory findings: hypercalcemia, hyperuricemia, hyposalemia, hyponatremia, hyperglycemia. Very rare: thrombocytopenia, leukopenia, agranulocytosis, bone marrow aplasia, and hemolytic anemia. Other: possible exacerbation of systemic lupus erythematosus.
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