Data on the use of ranolazine in pregnant women are not available. Penetration of ranolazine in breast milk has not been studied.
In the absence of data to use the drug primobolan dosage during pregnancy and lactation is contraindicated.
The tablets should be swallowed whole, drinking plenty of fluids, do not pulverize, without breaking or chewing. Food does not affect the bioavailability of the drug, so it can be taken without regard to meals.The recommended initial dose of the for adults is 500 mg two times a day. After 2-4 weeks the dose, if necessary, can be increased to 1000 mg two times a day. The maximum daily dose is 2,000 mg. When side effects caused by drug intake for example, dizziness, nausea, or vomiting), it is necessary to reduce the dose to 500 mg.If after that the symptoms do not disappear, use of the drug should be discontinued.For patients with chronic heart failure (III-IV functional class classification), with renal insufficiency mild to moderate (creatinine clearance 30-80 ml / min), hepatic insufficiency mild (5-6 points on a scale Child-Pugh) with patients weighing less than 60 kg, and patients over 65 years and for patients taking isoenzyme inhibitors and P-gp (P-glycoprotein), dose titration is recommended.
Side effects seen in patients taking in most cases characterized by mild or moderate severity and usually develop within the first 2 weeks of application.
The following are the side effects, which has been recognized as a possible link with .
On the part of metabolism and nutrition: Uncommon: decreased appetite, anorexia, dehydration. On the part of the psyche:Uncommon: anxiety, insomnia, dizziness, hallucinations. rare: disorientation . From the nervous system: Common: dizziness, headache. Uncommon: lethargy, syncope, hypoesthesia, somnolence, tremor, postural dizziness, paresthesia. rare: amnesia, confusion, loss of consciousness, gait ataxia, gait disturbance, parosmiya. With the organ of vision: Uncommon: blurred vision, visual disturbances, diplopia.On the part of the organ of hearing and labyrinth disorders: Uncommon: vertigo, tinnitus. rare: hearing loss. On the part of the cardiovascular system: Infrequent: “tides” of blood to the face , marked reduction in blood pressure. rare: cold extremities, postural hypotension. The respiratory system, organs, thoracic and mediastinal disorders: Uncommon: dyspnoea, cough, epistaxis. rare: feeling of constriction in the throat. On the part primobolan dosage of the digestive tract: Common: constipation, nausea , vomiting. Uncommon: abdominal pain, dryness of the oral mucosa, dyspepsia, flatulence, stomach discomfort.rare: pancreatitis, erosive duodenitis, hypoesthesia oral cavity. For the skin and subcutaneous tissue disorders: Uncommon: pruritus, rash. rare: allergic dermatitis, urticaria, cold sweat, skin rash, angioedema. From the musculoskeletal system: Uncommon: pain in the extremities, muscle cramps, swelling of the joints. rare: muscle weakness. On the part of the kidney and urinary tract:Uncommon: dysuria , hematuria, chromaturia. rare: acute renal failure, urinary retention. With the genitourinary system: rare: erectile dysfunction. General disorders: Common: asthenia. Uncommon:fatigue, peripheral edema. Other disorders: Uncommon: increased creatinine concentration in blood plasma , increasing concentrations of urea in blood plasma, lengthening the QTc interval primobolan dosage corrected, thrombocytosis and leukocytosis, weight loss. rare: increased activity of “liver” enzymes.