of acute poisoning symptoms mainly related to the water and electrolyte disturbances (hyponatraemia, hypokalaemia) and appear as nausea, vomiting, decreased blood pressure, cramps, dizziness, drowsiness, confusion, polyuria or oliguria, which might result in anuria (due to hypovolaemia). Treatment: activities to be removed from its preparation by gastric buy primobolan lavage and / or administration of activated charcoal. Subsequent events held in a medical facility should be aimed at restoring fluid and electrolyte balance, symptomatic therapy. No specific antidote.
Interactions with other drugs With simultaneous use: drugs lithium and indapamide careful monitoring of lithium plasma levels and dosage adjustment may increase the concentration of lithium in blood plasma with the symptoms of an overdose, as well as with a salt-free diet (decreased lithium urinary excretion). with astemizole, bepridinom, erythromycin (with on / in the introduction), halofantrine, pentamidine, sultopride, terfenadine and vincamine, antiarrhythmics IA class (quinidine, gidrohinidinom, disopyramide, amiodarone, bretiliumom, sotalol) – increases the likelihood of cardiac arrhythmias such as ” pirouette”. Risk factors are hypokalemia, bradycardia, and preceding the QT interval elongation. With nonsteroidal anti-inflammatory drugs (for systemic administration), high doses of salicylates – there is a risk of acute renal failure in dehydrated patients (decreased glomerular filtration rate). It is necessary to compensate for fluid loss at the beginning of the treatment and monitoring of renal function. With amphotericin B (w / w); glucose and mineralokortikosteroidami (at system assignment) tetrakozaktidom, laxative, stimulating bowel motility, cardiac glycosides – increase the risk of hypokalaemia (additive effect). Necessary to control the level of potassium in the ECG blood plasma, if necessary – the buy primobolan appointment of appropriate treatment.
Since baclofen – increased antihypertensive effect. With cyclosporine – increased creatinine concentration in blood plasma, with unchanged concentration of circulating cyclosporine. Tricyclic antidepressants, antipsychotics – enhanced antihypertensive effect of indapamide and increased the risk of orthostatic hypotension (additive effect). With the angiotensin-converting enzyme (ACE) – increase the risk of hypotension. With iodine-containing contrast agents (in high doses) – dehydration and increase the risk of developing acute renal failure. Before use of iodine-containing contrast agents to patients is necessary to compensate for fluid loss. Calcium salts – an increase in the concentration of calcium ions in the plasma due to the reduction of urinary excretion. Potassium-sparing diuretics (amiloride, buy primobolan spironolactone, triamterene) – the risk of hypokalemia or hyperkalemia, especially in patients with diabetes and patients with impaired renal function.